Frequently asked questions What are the medical marijuana laws in Mississippi? Mississippi passed Initiative 65 On November 3, 2020, legalizing the use of medical marijuana. A medical marijuana program is yet to be established in Mississippi, and there are no operational dispensaries as of yet. However, it was the more far-reaching, open, activist-lead Initiative that got voted in, and not the state’s own proposed Initiative. This is a positive sign! THC-free CBD oil is available in Mississippi at this current time.