Can Cannabis Be Used to Replace Addictive Pharmaceuticals?


Perhaps one of the most interesting things about cannabis is its safety profile: there hasn’t been a death via overdose attributable to the use of cannabis alone. This means that cannabis has a lower lethal dose than even benign, over-the-counter (OTC) drugs like acetaminophen and ibuprofen. This could be due to the unique way in which phytocannabinoids interact with the human body and the endocannabinoid system (ECS), often approximating the effects of other drugs like opioids and benzodiazepines but with fewer of the damaging side-effects.

With this in mind, cannabis – or more specifically cannabinoids and terpenoids – could be used to reduce or even replace entirely the need for prescription or OTC drugs with fewer undesirable side-effects.

Overview of report

The numbers of people who used marijuana to replace or reduce intake of their medications


Reasons for Taking Medical Marijuana


patients reported using cannabis help with



patients reported using cannabis help with



patients reported using cannabis help with


Top conditions that patients have replaced prescriptions for MMJ

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Dr. Frank D’Ambrosio


Frank D’Ambrosio, M.D., has over 20 years of experience as an orthopaedic surgeon. He now dedicates his practice to advocating for and helping patients who may benefit from the use of medical marijuana.

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49 pages - PDF (9,6MB)


  • The Endocannabinoid System (ECS), Clinical Endocannabinoid Deficiency (CEDC) and the “Entourage Effect”
  • Cannabis: an Intriguing Risk:Benefit Ratio
  • On Strains and Cannabinoid and Terpenoid Profiles
  • Benefits of Cannabis Legalization, Medically or Otherwise
  • Patients and Methods
  • Results