Everything You Need To Know About The Negative Side-Effects of Medical Marijuana

Medical marijuana, like any other medication, can have side-effects. Of course, side-effects such as being pain-free and being able to eat and sleep properly are positive ones. Other side-effects, however, are not so desirable. Here is a description on some of the most common side-effects

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Tetrahydrocannabinol’s (THC’s) Side-Effects – THC Oils, Edibles, Pills, High-THC Strains etc.

THC’s side-effects are usually the most obvious – not surprising, seeing as it is the prominent psychoactive cannabinoid found in cannabis. At low doses of around 3 mg or less, THC may have little-to-no psychoactive effect, although there may be a slight feeling of euphoria. Some people start at a dose of around 3 mg-5 mg THC when using edibles or tinctures, where there may be some euphoric and anxiolytic effect, but to a manageable level. Another is to utilize delta-8 THC, which is not as psychoactive as delta-9 THC and is still a natural cannabinoid.

For most people, the main problems with THC come when too much is ingested too quickly. Sleepiness, lethargy, feeling hot and sweaty or cold, anxiety, paranoia, “cotton” or “dry” mouth (i.e. a lack of saliva in the mouth), the “munchies” (extreme hunger pangs), a sense of a loss of self, short-term memory loss, dry, red eyes and, more rarely, dizziness and nausea are the most common negative side effects, although sleepiness and hunger pangs can be beneficial for certain conditions. An increase in heart rate, followed by a decrease, is also common.

As for the likelihood of experiencing a psychotic episode, this is only likely to occur in those who are already predisposed to conditions where psychosis may be an issue (e.g. schizophrenia). For children and adolescents, exposure to high amounts of THC on a regular basis may have some long-term effects on memory, mood and behaviour, as the brain is still developing. For those aged 25 and over, however, the long-term effects of THC are not known (as is the case with many medications). Indeed, there may even be neurogenic effects when small doses of THC are used by older people. The negative effects on IQ and memory generally occur when the user is young. Longitudinal studies have shown littlelong-term effects on executive functioning.

Eating cannabis also tends to have longer lasting and stronger effects than other ingestion methods. Whilst vaporizing, inhaling or smoking small amounts of THC can provide a more immediate effect, they are not necessarily the healthiest methods of ingestion. Tinctures, topicals, transdermal patches, inhalers, suppositories and all the ingestion methods associated with the usual ways of taking medicine can often provide a more controlled release of THC; but, with a few exceptions, finding a company that produces a properly standardized product that releases a specific dose upon every application is difficult.

Fortunately, the side-effects of taking too much THC are not life-threatening. Staying hydrated, eating well, keeping relaxed and not worrying too much is often the best strategy. Some people use black peppercorns for their pinene and beta-caryophyllene to beat anxiety and lessen some of the effects negative effects of THC. CBD is also used to dampen the effects of THC, usually by taking equal amounts of CBD to the amount of THC ingested.

However, although CBD can reduce THC’s anxiety-inducing properties, in small doses and in combination with THC, it can prolong THC’s effects to a certain extent whilst also lessening its more paranoia-inducing effects to a smaller extent. Small amounts of THCV may also be used, as it is a CB1 receptor antagonist at low doses. However, at high doses, THCV is a CB1 receptor agonist and so has psychoactive effects, making it difficult to control. So, basically, as with any other medication, dosing cannabis matters.

THC; tetrahydrocannabinol; THC isomer.
By RobinLeclercq. Source

Cannabidiol’s (CBD’s) Side-Effects

CBD is an interesting compound. Although not psychoactive in the same sense that THC is, the fact that CBD has a physiological effect means that CBD does have some sort of psychoactive effect – just not one that seems to cause a significant alteration in perception. Some potential side-effects of CBD include low blood pressure, lightheadedness, drowsiness or even wakefulness and feeling “jittery” if high doses are used. There is some evidence suggesting that using bad quality, hemp-based CBD may increase the rate of seizures for those with epilepsy. CBD may also lower body temperature

In some instances, Parkinson’s patients may feel an increase in their tremors, whilst high doses of CBD may actually increase intraocular pressure in glaucoma patients. However, perhaps the main problem with CBD is not necessarily its side-effects – it is the fact that it inhibits hepatic drug metabolism and decreases the activity of p-glycoprotein transporters. CBD desensitizes the liver enzyme cytochrome P450, which is required to process a lot of different drugs and medications.

CBD’s main side-effect, therefore, mostly involves negative drug interactions, as opposed to its physiological effects. Little is known about the long-term side-effects of consuming CBD, although current studies suggest that it is generally well-tolerated and safe for most people.

Grapefruit juice; drug interactions; how grapefruit interacts with drugs; negative drug interactions; liver enzymes; small intestine enzymes; drug metabolism.
Graphic courtesy of the US FDA.

What is a Cannabis Hangover?

Cannabis is not usually associated with hangovers, at least in the traditional, alcohol-related sense. After all, you tend not to get the headaches, nausea/vomiting and dehydration associated with alcohol. Yet, for anyone who’s used cannabis for long enough, they will realize that the residual effects of cannabis can be felt into the next day. Very rarely is a cannabis hangover painful (headaches and nausea are possible, but not common), but forgetfulness and “brain fog” is often experienced. Usually, the best way to overcome a cannabis hangover is by staying hydrated, fresh air and some sort of physical exertion. Green tea may help, as could peppery or spicy food, but this is anecdotal and may depend upon the individual.

Dehydration; hangover; the night after; too much alcohol; too much cannabis.

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Is Cannabis Addictive?

We have gone over this concern many times, but it is worth reiterating: cannabis is not physically addictive, although around 9% of regular users can develop a psychological addiction called cannabis misuse disorder. Occasional use does not seem to be addictive, and even regular use is not a major concern in controlling use for most people who are in their late 20s. On the whole, cannabis is far less addictive than alcohol, tobacco, benzodiazepines, opioids and some would even say coffee!

Age does seem to be a factor when it comes to cannabis misuse disorder. Those who use cannabis (and in particular high-THC varieties) during their teen years are more likely to develop cannabis misuse disorder – about 18% of those who start using cannabis in their teen years develop the disorder.

Those who suffer from addiction tend to have depleted levels of dopamine receptors. THC does increase dopamine production, and regular use of high amounts of THC may reduce dopamine brain reactivity. However, different cannabinoids effect dopamine in a variety of ways, and they do so in a way distinct from drugs like cocaine or alcohol. Not all cannabinoids are psychoactive, so are not likely to have much if any abuse potential. With THC, the amount of dopamine released is generaly far lower than with other substances of abuse, and some of its harm can be mitigated by other cannabinoids and terpenes. Most of the abuse potential associated with cannabis seems to come from non-medical use of high-THC cannabis varieties in younger people.

Addiction; dopamine; dopamine receptors; pleasure; reward; dopamine depletion in addiction.
By Debra P. Davis. Source 
Depletion of dopamine receptors due to drug addiction.

Can You Overdose on Cannabis?

When it comes to the natural phytocannabinoids made by the actual cannabis plant, there is only a theoretical chance of a deadly overdose if cannabis is used on its own – it would take consuming around 1500 pounds of cannabis to induce a lethal response. The endocannabinoid system (ECS) breaks down cannabinoids very rapidly, meaning that dangerous levels of cannabinoids are never really reached.

When it comes to synthetic cannabinoids, it seems that it is certainly possible to overdose on them. This is because some types of synthetic cannabinoids can shut down some of the human body’s essential processes – the ECS is intimately involved with homeostasis, after all, and desensitizing or shutting off the wrong part of it can cause some major health problems, or even death. For this reason, care must be taken with synthetic cannabinoids, even in clinical settings. The plant matter that is sprayed with synthetic cannabinoids and sold as “incense” or as a “herbal alternative” to cannabis is to be avoided, and really should not be seen as similar to natural cannabis in any way whatsoever.

Overdose; drugs; pills.
By HastyWords. Source.

Any Other Potential Side-Effects?

Sadly, we do not know enough about the pharmacology of every single cannabinoid to determine how each one affects us precisely, especially in the long term. The matter gets even more complicated when you start mixing different cannabinoids and terpenoids, as they all influence the way in which other cannabinoids behave. High doses of CBG may cause nausea and block the antiemetic effects of THC,

There is also cannabinoid hyperemesis syndrome (CHS), but the condition is extremely rare and how it is caused precisely specifically is not known. So far, it is mostly THC that has been implicated in the development of CHS (CBD may increase CB1 receptor expression in the brain and therefore lead to a greater amount of receptors being exposed to THC and its hypothermic effects), and consumption must be regular and heavy – CHS has not been associated with consumption of unheated cannabinoids.

Can a person be allergic to cannabis, or specific cannabinoids and terpenes?

Yes, this is entirely possible. Some people may be allergic to the pollen of the plant, whereas others may be allergic to a specific terpene/terpenoid or other compound in the cannabis plant. As for the cannabinoids themselves, it is entirely possible that a person may be particularly sensitive, allergic or intolerant to a specific cannabinoid or set of cannabinoids. Research in this area is very much needed.

Supplements; how dangerous are supplements; supplements danger hierarchy; triangle.pyramid of supplement danger.
Supplements ranked according to potential danger. By Airman 1st Class Kedesha Pennant, 7th Bomb Wing Public Affairs

As everybody’s ECS is different and the pharmacology of cannabinoids is varied and complex, some people may get side-effects that others do not. Overall, though, cannabis is generally very well tolerated and you cannot have a deadly overdose on it when used alone. There are few if any substances on this Earth with the safety profile of cannabis, which is why its medical potential is so exciting. However, the only way we’re going to know how safe cannabis truly is, is by removing the barriers to researching the plant properly and without fear of the law.

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Written by
Dipak Hemraj
Dipak Hemraj

Dipak Hemraj is a published author, grower, product maker, and Leafwell’s resident cannabis expert. From botany & horticulture to culture & economics, he wishes to help educate the public on why cannabis is medicine (or a “pharmacy in a plant”) and how it can be used to treat a plethora of health problems. Dipak wants to unlock the power of the plant, and see if there are specific cannabinoid-terpene-flavonoid profiles suitable for different conditions.

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