Multiple Sclerosis (MS)

– MS is a demyelinating disease, where the myelin sheath that protects and nerve cells is damaged. This impairs the conduction of signals across nerve cells, and over time can cause persistent muscle spasms and consistent nerve pain.

– MS is a condition where the body’s immune system attacks the body’s immune system.T-cells become activated in the lymph system, and, for those with MS, enter the central nervous system (CNS). Once in the CNS, the chemicals released by T-cells cause inflammation and damage.

– T-cells activate helper B-cells, which activate antibodies and cause further damage to the CNS and the myelin sheath surrounding nerves.

– T-regulatory cells dampen or turn off inflammation. In those with MS, these T-regulatory cells do not function properly.

– There are a number of factors that could cause multiple sclerosis, although the precise cause or causes are not known. Genetics are definitely a factor, and there are approximately 200 genes that have been identified that where abnormalities could contribute to the development of MS. Environmental factors and having suffered a previous major condition may also be a factor in the development of MS.

– Symptoms of MS include vision problems and possibly blindness over time. Fatigue, numbness, tingling, muscle spasms, mobility problems, confusion and problems with thinking & planning, depression and anxiety and nerve and muscle pain.

– Onset of MS is usually between 20 and 40 years of age, but can arise at any age from 10 years old to 80 years old, with a mean of 32 years old.

– Symptoms can build over time in a progressive manner in those with MS.

– In some cases, MS occurs in recurring, isolated attacks.

– MS is the most common autoimmune disorder affecting the central nervous system (CNS).

– Approximately 2.5 million people worldwide suffer from MS.

– The US makes up around 400,000 of total worldwide sufferer.

– Rates of MS are higher farther from the equator.

– According to Healthline, 200 new cases of MS arise in the US each week.

– There is  a medication in the UK developed for MS using THC, named Sativex. Sativex may also be of use for the neuropathic pain associated with MS. Sativex is produced by GW Pharmaceuticals, and is approximately 1:1 THC: CBD ratio.

– THC may help with reduce the number of spasms and help reduce pain. CBD may help reduce some of the psychoactive effects of THC when in equal ratios, and thus help reduce some of the more confusing and fatiguing effects of THC.

– Cannabinoids’ could help promote neurogenesis for older people, and so could be of use for those in MS.

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